Psalm 2:1 says, "Why do the nations rage and the peoples plot in vain?"
People want independence so much that nations are forever raging and people are forever fighting to gain it. Whether it's from foreign leaders like Americans did during the Revolutionary War or teenagers from parents, we are always trying to get out from under the control of others.
The Psalm continues, "The kings of the earth set themselves, and the rulers take counsel together, against the Lord and against his Anointed, saying 'Let us burst their bonds apart and cast away their cords from us."
I think this Psalm is really important today. Groups of people are banding together to try and get rid of every hint of religion, especially Christianity, from this country. Students can't write about their faith in papers or pray in class. The military can't put up a cross for a memorial. People don't even want to say "under God" in the Pledge of Allegiance.
People are constantly banding together against God and against his Anointed, Jesus. However, the first part of this Psalm is most important - "Why do the nations rage and the people plot in vain?" It's all in vain.
Any kind of struggle against God is in vain. People have a choice not to accept Christ, and they might think they have won on Earth. However, the moment they die they will see that their struggle against the one who created the heavens and the earth was in vain. They will receive their punishment eventually.
Even the Devil's ruses are in vain. He might have some temporary victories in life, but his struggles against God will eventually lead him to a lake of fire. God will win.
If you're struggling against God right now, realize that it's in vain. It's a lot of work for no gain.